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Department of Molecular Biology and Biochemistry
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Leroux Lab

The focus of our studies is to identify and characterise proteins found within the cilium, an evolutionarily ancient microtubule-based organelle found on virtually all human cells. 

Using the nematode C. elegans, we study intraflagellar transport, a kinesin- and dynein-dependent transport process necessary to form and maintain the complex ciliary structure. We also aim to understand the makeup and function of the transition zone, a 鈥榞ate鈥� that controls ciliary composition and thus function. Importantly, our biomedical research probes the molecular basis of several human disorders arising from ciliary dysfunction, including Bardet-Biedl Syndrome and Meckel syndrome. Such 鈥榗iliopathies鈥� are characterised by a wide range of ailments, such as obesity, kidney and heart anomalies, blindness, skeletal malformations, and neurosensory impairment.

For more information, visit our .

Email: 

MICHEL LEROUX
leroux@sfu.ca

Lab Room:

SSB 6144

Lab Phone: 

(778) 782-5785

Selected Publications

  • Chrystal PW, Lambacher NJ, Doucette LP, Bellingham J, Schiff ER, Noel NCL, Li C, Tsiropoulou S, Casey GA, Zhai Y, Nadolski NJ, Majumder MH, Tagoe J, D'Esposito F, Cordeiro MF, Downes S, Clayton-Smith J, Ellingford J; Genomics England Research Consortium; Mahroo OA, Hocking JC, Cheetham ME, Webster AR, Jansen G, Blacque OE, Allison WT, Au PYB, MacDonald IM, Arno G, Leroux MR. The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision.
  • Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. 
  • Canning P, Park K, Gon莽alves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. 
  • Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivi猫re JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM, Leroux MR. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. 
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