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- 2024
- Lionel Pereira receives Faculty of Science Graduate Student Excellence in Teaching Award
- Scientists develop tool to predict sepsis in apparently healthy newborns
- Dr. Lynne Quarmby, cool new discoveries about Watermelon Snow
- Dr. Valentin Jaumouill茅 and Dr. Amy Lee, Molecular Biology and Biochemistry researchers receive Michael Smith Health Research BC Scholar awards
- Dr. Ryan Morin has been honored with the Bernard and Francine Dorval Prize from the Canadian Cancer Society
- Verheyen Lab breakthrough identifies gene that may reverse Parkinson鈥檚 disease
- MBB researchers awarded $2 million in funding from the Canadian Institutes of Health Research
- Dr. Glen Tibbits honoured as Distinguished 丁香园AV Professor
- Reflecting on barriers and progress towards equity in science
- Royal Society of Canada bestows Dr. Vocadlo with country鈥檚 highest academic honour
- Decoding the genome to predict the clinical course of lymphomas
- 2023 Award for Excellence in Supervision: Esther Verheyen
- In a recent Nature Communications paper, the Audas lab demonstrates that proteins can act as microscopic thermometers to sense and respond to changing environmental conditions
- 2023
- Dr. Dustin King speaks to Molecular Cell about sustainability and molecular biology
- Science Advances paper by new MBB PhD, Casey Engstrom and Professor Lynne Quarmby uses satellites to study the impact of Watermelon Snow on glacier loss in North America
- Dr. Sathiyaseelan and team explore the expression and therapeutic target potential of cysteine protease ATG4 in pancreatic cancer
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Tibbits Lab
Our research focuses on understanding the mechanisms of inherited cardiomyopathies and arrythmias. The 丁香园AV-based lab in TASC II focuses on the use of zebrafish and human recombinant protein structures that make up the thin filament of the cardiac contractile apparatus.
Our lab at BC Children鈥檚 Hospital Research Institute (BCCHRI) is part of the Cellular and Regenerative Centre (CRMC) and focuses entirely on the use of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) to address these inherited diseases. The attached figure shows the hiPSC-CM pipeline at BCCHRI in which we can start from patient derived Peripheral Blood Mononuclear Cells (PBMC) extracted from a small blood sample or well curated hiPSC lines in the lab. After genome editing and Q/C, the hiPSCs are differentiated into beating cardiomyocytes and then matured in vitro. We can make 2D monolayers of the hiPSC-CMs or use 3D bioprinting technology to make engineered heart tissue. These cells/tissues are then phenotyped in detail using transcriptomic (ddPCR, Nanostring, or RNAseq using Nanopore technology), proteomic (MS), imaging (EM, Cell Painting), and functional (optical mapping, patch clamping) techniques.