丁香园AV

Education

• B.Sc. (Hons), 丁香园AV (2010)
• Ph.D., University of British Columbia (2015)
• Postdoctoral Research Fellow, TRIUMF (2015 鈥� 2018)

Lab Information

• LAB: C8065
• TEL: 778-782-4403

Research

Nuclear Medicinal Inorganic Chemistry

Nuclear medicine is a powerful technique with the ability to both image disease non-invasively and subsequently treat the diseased state by injecting a radioactive isotope fused to a designer molecule that can transport the radionuclide specifically to the diseased tissue.  Our research focuses on the development of novel pharmaceuticals which incorporate radioactive metal ions (aka radiometals) for both molecular imaging and targeted therapy of disease. We design, synthesize, characterize, and evaluate (in vitro and in vivo) metal-based radiopharmaceuticals, with an emphasis on understanding the coordination chemistry used to tether the radiometal ion to the biomolecular targeting vector (Figure 1). This interdisciplinary research bridges the fields of chemistry, biology, and radiology. We work closely with our collaborators at TRIUMF 鈥� Canada鈥檚 particle accelerator centre () 鈥� to produce innovative and unconventional radiometals, and BC Cancer 鈥� to evaluate our radiopharmaceuticals in vivo.

To learn further about our research directions please visit the  (and check out  鈥� a short documentary about Actinium-225, a promising alpha-emitting radionuclide that can be used for targeted therapy, and one of our research foci).

We are looking for enthusiastic undergraduate and graduate students to join our program!

Publications

1. Wang, X., Jaraquemada-Pel谩ez, M. de G., Rodr铆guez-Rodr铆guez, C., Cao, Y., Buchwalder, C., Choudhary, N., Jermilova, U., Ramogida, C. F., Saatchi, K., H盲feli, U. O., Patrick, B. O., Orvig, C. (2018) H₄octox: Versatile Bimodal Octadentate Acyclic Chelating Ligand for Medicinal Inorganic Chemistry.  J. Am. Chem. Soc. 140, 15487-15500.

2. Robertson, A.K.H., Ramogida, C.F, Schaffer, P., Radchenko, V. (2018) Development of ²²⁵Ac radiopharmaceuticals: TRIUMF perspectives and experiences. Current Radiopharmaceuticals. 11, 156-172. DOI:10.2174/1874471011666180416161908

3. Dias, G.M., Ramogida, C.F., Rousseau, J., Zacchia, N.A., Hoehr, C., Schaffer, P., Lin, K.-S., B茅nard, F. (2018) ⁸⁹Zr for antibody labelling and in vivo studies 鈥� a comparison between liquid and solid target production. Nuclear Medicine and Biology, 58, 1 鈥� 7.  doi: 10.1016/j.nucmedbio.2017.11.005.

4. Thiele, N.A., Brown, V., Kelly, J.M., Amor-Coarasa, A., Jermilova, U., MacMillan, S.N., Nikolopoulou, A., Ponnala, S., Ramogida, C.F., Robertson, A.K.H., Rodr铆guez-Rodr铆guez, C., Schaffer, P., Williams, C.Jr., Babich, J.W., Radchenko, V., Wilson, J.J. (2017) An Eighteen-membered macrocyclic ligand for actinium-225 targeted alpha therapy. Angewandte Chemie., 57, 14712 鈥� 14717. doi: 10.1002/anie.201709532 and 10.1002/ange.201709532.

5. Comba, P., Jermilova, U., Orvig, C., Patrick, B. O., Ramogida, C.F., R眉ck, K., Schneider, C., Starke, M. (2017) Octadentate picolinic acid-based bispidine ligand for radiometal ions. Chemistry A European Journal, 23, 15945-15956. doi: 10.1002/chem.201702284.

6. Spreckelmeyer, S., Ramogida, C.F., Rousseau, J., Arane, K., Bratanovic, I., Colpo, N., Jermilova, U., Dias, G.M., Dude, I., Jaraquemada-Pel谩ez, M. de G., B茅nard, F., Schaffer, P., Orvig, C. (2017) p-NO₂-Bn-H₄neunpa and H₄neunpa-trastuzumab: Bifunctional chelator for radiopharmaceuticals and ¹¹¹In immuno-SPECT imaging. Bioconjugate Chemistry, 28, 2145-2159.

7. Robertson, A.K.H., Ramogida, C.F., Rodriguez-Rodriguez, C., Blinder, S., Kunz, P., Sossi, V., Schaffer, P. (2017) Multi-isotope SPECT imaging of the ²²⁵Ac decay chain: feasibility studies. Physics in Medicine and Biology, 101, 158-162.

8. Weekes, D.M., Ramogida, C.F., Jaraquemada-Pel谩ez, M.G., Patrick, B.O., Apte, C., Kostelnik, T.I., Cawthray, J.F., Murphy, L., Orvig, C. (2016) Dipicolinate complexes of gallium(III) and lanthanum(III). Inorganic Chemistry, 55, 12544-12558.

9. Ramogida, C.F., Schindler, D., Schneider, C., Tan, Y.L.K., Huh, S., Ferreira, C.L., Adam, M.J., Orvig, C. (2016) Synthesis and characterization of lipophilic cationic Ga(III) complexes based on the H₂CHXdedpa and H₂dedpa ligands and their ^67/68Ga radiolabeling studies. RSC Advances, 6, 103763-103773.

10. Ramogida, C.F., Boros, E., Patrick, B.O., Zeisler, S. K., Kumlin, J., Adam, M.J., Schaffer, P., Orvig, C. (2016) Evaluation of H₂CHXdedpa, H₂dedpa- and H₂CHXdedpa-狈,狈鈥�-propyl-2-NI ligands for ⁶⁴Cu(II) radiopharmaceuticals. Dalton Transactions, 45, 13082-13090.

11. Ramogida, C.F., Murphy, L., Cawthray, J.F., Ross, J.D., Adam, M.J., Orvig, C. (2016) Novel 鈥渂i-model鈥� H₂dedpa derivatives for radio- and fluorescence imaging. Journal of Inorganic Biochemistry, 162, 253-262. Invited for Prof. G. R. Hanson Memorial issue.

12. Ramogida, C.F., Pan, J., Ferreira, C. L., Patrick, B.O., Rebullar, K., Yapp, D.T.T., Lin, K-.S., Adam, M.J., Orvig, C. (2015) Nitroimidazole-containing H₂dedpa and H₂CHXdedpa derivatives as potential PET imaging agents of hypoxia with ⁶⁸Ga. Inorganic Chemistry, 54, 4953-4965.

13. Ramogida, C.F., Cawthray, J.F., Boros, E., Ferreira, C.L., Patrick, B.O., Adam, M.J., Orvig, C. (2015) H₂CHXdedpa and H₄CHXoctapa 鈥� Chiral acyclic chelating ligands for ^67/68Ga and ¹¹¹In radiopharmaceuticals. Inorganic Chemistry, 54, 2017-2031.

14. Ramogida, C.F., Orvig, C. (2013) Tumour targeting with radiometals for diagnosis and therapy. Chemical Communications, 49, 4720-4739.

15. Price, E.W., Zeglis, B.M., Cawthray, J.F., Ramogida, C.F., Ramos, N., Lewis, J.S., Adam, M.J., Orvig, C. (2013) H₄octapa-Trastuzumab: Versatile acyclic chelate system for ¹¹¹In and ¹⁷⁷Lu imaging and therapy. Journal of the American Chemical Society, 135, 12707-12721.

16. Dunn, T.J., Chiang, L., Ramogida, C.F., Hazin, K., Webb, M.I, Katz, M.J., Storr, T. (2013) Class III delocalization and exciton coupling in a bimetallic bis-ligand radical complex. Chemistry 鈥� A European Journal, 19, 9606-9618.

17. Dunn, T.J., Chiang, L., Ramogida, C.F., Webb, M.I., Savard, D., Sakaguchi, M., Ogura, T., Shimazaki, Y., Storr, T. (2012) Non-innocent ligand behaviour of a bimetallic Cu complex employing a bridging catecholate. Dalton Transactions, 41, 7905-7914.

18. Dunn, T.J., Ramogida, C.F., Simmonds, C., Paterson, A., Wong, E.W.Y., Chiang, L., Shimazaki, Y., Storr, T. (2011) Non-innocent ligand behaviour of bimetallic Ni Schiff-base complex containing a bridging catecholate. Inorganic Chemistry, 50, 6746-6755.

19. Shimazaki, Y., Arai, N., Dunn, T.J., Yajima, T., Tani, T., Ramogida, C.F., Storr, T. (2011) Influence of the chelate effect on the electronic structure of one-electron oxidized group 10 metal(II)-disalicylidene diamine complexes. Dalton Transactions, 40, 2469-2479.

20. Van Donkersgoed, J., Sit, D., Gibbons, N., Ramogida, C., Hendrick, S. (2010) Drug residues recovered in feed after various feedlot mixer truck cleanout procedures. Journal of Food Protection, 6, 75-80.