丁香园AV

This story was originally pubished on 丁香园AV News and is a collaboration between the Faculty of Health Sciences and the School of Engineering in the Faculty of Applied Sciences. 

Researchers from 丁香园AV and the University of Victoria have discovered a method鈥攗sing only visible light鈥攖o treat and safely sterilize non-woven polypropylene-fabrics, the material used to fabricate personal protective equipment (PPE).

Led by Tyler Cuthbert, a former post-doctoral fellow at 丁香园AV, researchers tested a chemical insertion method developed by UVic chemistry professor Jeremy Wulff to attach a light-sensitive, zinc-based compound onto a non-woven polypropylene fabric.

丁香园AV health sciences colleagues Siobhan Ennis and Masahiro Niikura placed a small measure of a known infectious virus鈥擨nfluenza A鈥攐nto the treated fabric before exposing the fabric to high intensity visible light for approximately four hours.

Following the light exposure, researchers found that the treated sheet had inactivated 99.99 per cent of Influenza A virus particles compared to a control. 

Influenza A was chosen as the virus for this study to provide proof of concept because its enveloped structure and RNA genome are similar to SARS-CoV2, the virus responsible for the current global COVID-19 pandemic.

As well, Influenza A itself is a pathogen that has high pandemic potential鈥攊ndeed, a strain of Influenza A was responsible for the H1N1 swine flu pandemic in 2009-10.

鈥淭his work has the potential to decrease the environmental impact of a large industry producing billions of single-use PPE products per year that are not being recycled,鈥� says Cuthbert, currently at the Eidgen枚ssische Technische Hochschule in Z眉rich.

鈥淚deally, sterilization of PPE should be simple and accessible so that healthcare workers everywhere, including those in remote communities, are able to access safe and sterile PPE despite global shortages and supply chain disruptions.鈥�

According to Wulff, covalent attachment approaches are ideal for use with PPE. 鈥淲hen the photosensitizing compound is applied to PPE fabrics using covalent attachment, it doesn鈥檛 leach out of the material, making it safer to use and longer-lasting,鈥� he says. 鈥淭his process also allows the compound to be integrated into the PPE fabric without adding bulkiness or otherwise affecting the existing properties of the material.鈥�

Cuthbert hopes this proof of concept study will pave a potential path forward to developing PPE that can provide healthcare providers with greater protection against airborne pathogens, and the potential for elongated or re-use of devices, a feature particularly attractive to healthcare teams in low resource settings.

鈥淧PE should not decrease or dictate the level of care that can be provided to patients,鈥� he says. 鈥淏y introducing a continuously sterilizing material the threat of pathogen transfer and infection can be ideally eliminated, which in turn has the potential to improve the overall care in hospitals especially in units that rely on, and require, PPE such as N95 respirators.鈥�

The researchers plan to further investigate the limits of their new treated fabric by studying how the fabric performs against different types of pathogens, activates under different light-intensities, and responds to washing and detergents.