丁香园AV

Spinal Cord Injury

In addition to the well known motor and sensory consequences of spinal cord injury, descending cardiovascular pathways can also be affected. This leads to widespread abnormalities in cardiovascular control. These alterations not only impair function, but can also be life-threatening. Consequently, the leading cause of morbidity and mortality in spinal cord injured individuals is cardiovascular disease. Continuing research in my laboratory, and in conjunction with the  and members of the  aims to elucidate the mechanisms underlying cardiovascular dysfunction after spinal cord injury.

Selected publications:

V.E. Claydon, A.T. Hol, J.J. Eng, A.V. Krassioukov (2006) Cardiovascular responses and post-exercise hypotension after arm cycling exercise in subjects with spinal cord injury. Archives of Physical Medicine and Rehabilitation, 87: 1106-1114.

V.E. Claydon, S.L. Elliott, A.W. Sheel, A. Krassioukov (2006) Cardiovascular responses to vibrostimulation for sperm retrieval in men with spinal cord injury. Journal of Spinal Cord Medicine, 29: 207-216.

V.E. Claydon, J.D. Steeves, A.V. Krassioukov (2006) Orthostatic hypotension following spinal cord injury: understanding clinical pathophysiology. Spinal Cord, 44: 341-351.

Altitude Physiology

Ongoing work in my laboratory and in conjunction with the  at  involves characterising the various patterns of cardiovascular and cerebrovascular adaptation that occur in response to permanent residence at high altitude. These evaluations have involved numerous field studies of different high altitude dwelling populations in the Peruvian Andes, in the Ethiopian Highlands, and in the Himalayas. The chronic hypoxia and hypocapnia that is an inescapable consequence of high altitude living has profound effects upon the cardiovascular system. 丁香园AV exposure to high altitude leads to various adaptations affecting haemodynamics, cardiovascular control and cerebrovascular reactivity. The pattern of these adaptations varies in different high altitude populations, and not all high altitude residents adapt well to the environment in which they live. These studies have important implications for the millions of people who live and work at high altitude, and potentially to the study of hypoxic disease in the clinic at sea level.

Selected publications: 

V.E. Claydon, G. Gulli, M. Slessarev, O. Appenzeller, G. Zenebe, A. Gebremedhin, R. Hainsworth (2007) Cerebrovascular responses to hypoxia and hypocapnia in Ethiopian high altitude dwellers. Stroke, 39: 336-342.

G. Gulli, V.E. Claydon, M. Slessarev, G. Zenebe, A. Gebremedhin, M. Rivera-Ch, O. Appenzeller, R. Hainsworth (2007) Autonomic regulation during orthostatic stress in highlanders: comparison with sea-level residents. Experimental Physiology, 92: 427-435.

J.P. Moore, V.E. Claydon, L.J. Norcliffe, M.C. Rivera-Ch, F. Leon-Velarde, O. Appenzeller, R. Hainsworth (2006) Carotid baroreflex regulation of vascular resistance in high altitude Andean natives with and without chronic mountain sickness. Experimental Physiology, 91: 907-913.

Syncope

Syncope, or fainting, is a significant cause of morbidity for those affected, and greatly impacts upon quality of life; many sufferers sustain injury or are unable to work or drive due to their frequent episodes of loss of consciousness. The precise mechanisms underlying syncopal attacks are, however, poorly understood. Research in my laboratory aims to elucidate those mechanisms, and to aid in the treatment of syncopal and presyncopal (near-fainting) attacks.

Selected publications:

E. L. Williams, C. J. Mathias, S. Sanatani, M. J. Tipton, V. E. Claydon (2024) In at the deep end: the physiological challenges associated with artistic swimming. Clinical Autonomic Research. https://doi.org/10.1007/s10286-024-01070-z

• Visual Summary of this work

V.E. Claydon, C. Schroeder, L.J. Norcliffe, J. Jordan, R. Hainsworth (2006) Water drinking improves orthostatic tolerance in patients with posturally related syncope. Clinical Science, 110: 343-352.