丁香园AV

Physiology & Pathophysiology of Motor Control

Brain Research Laboratory

The Brain Research Lab applies neurophysiological and cell biological methods to better understand nervous system function and dysfunction.

Current projects include: characterization of a cation current in neurons in health and disease, evaluation of the roles of protein and lipid kinases in a cell culture model of excitotoxicity, and determination of the role of protein kinases in an animal model of motoneuron disease.

Recent Publications:

• Hasham MI, Pelech SL and Krieger C (1997). Glutamate-mediated activation of protein kinase C in hippocampal neurons. Neurosci. Lett. 228: 115-118.
• Wagey R, Krieger C, and Shaw CA (1997). Abnormal dephosphorylation effect of NMDA receptor regulation in ALS spinal cord. Neurobiology of Disease.
• Lanius RA, Wagey R, Sahl B, Beattie BL, Feldman H, Pelech SL, and Krieger C (1997). Protein kinase C activity and protein levels in Alzheimer's disease. Brain Res.
• Hasham MI, Pelech SL, Koide HB and Krieger C (1997). Activation of protein kinase C by intracellular free calcium in the motoneuron cell line NSC-19. Biochem. Biophys. Acta 1360: 177-191.
• Yoo, ASJ, McLarnon, JG, Xu L, Lee YB, Krieger C, and Kim SU (1996). Effects of phorbol ester on intracellular Ca2+ and membrane currents in cultured human microglia. Neurosci. Lett. 218: 37-40.
• Dore S, Krieger C, Kar S, and Quirion R (1996). Distribution and levels of insulin-like growth factor (IGF-1 and IGF-II) and insulin receptor binding sites in the spinal cords of amyotrophic lateral sclerosis (ALS) patients. Mol. Brain Res. 41: 128-133.
• Krieger C, Lanius RA, Pelech SL, and Shaw CA (1996). Amyotrophic lateral sclerosis: the involvement of intracellular CA2+ and protein kinase C. Trends in Pharmacol. Sci. 17: 114-120.