丁香园AV

offered Fall 2015
A review of recent research on the structure, dynamics, function and biosynthesis of membranes, membrane lipids and proteins. Prerequisite: MBB 322 and MBB309W.

MBB 423-3 Protein Structure and Functionoffered Spring 2015
Through examination of modern research literature, students will learn to assess primary literature reports of structure data, and to formulate hypotheses and apply structural reasoning in investigations of molecular mechanism.Prerequisite: MBB 323 or MBB 324.

MBB 424-3 Membrane Transport Mechanisms 
Structure and function of molecules that mediate transport across membranes including channels, carriers, and pumps. Primary literature from the fields of biochemistry and physiology will be explored through lectures and independent study. Prerequisite: MBB 321, 322 and either MBB 323 or CHEM 360 with a minimum grade of C. Students who have taken MBB 420 under the same topic may not take this course for further credit.

offered Fall 2015
The basic organization of the immune system, including structure, function and genetics of antibodies, T-cell receptors, innate immune receptors, and the complement system. Innate, antibody and cellular immune responses and their control, and development of the cells involved in these responses. Prerequisite: MBB 331 with a minimum grade of C. Students who have taken HSCI 325 or 426 cannot take MBB 426 for further credit.

  offered Spring 2016
The immunologic response to bacterial, viral and parasitic infections, immunological diseases, such as autoimmune diseases, immunodeficiency, hypersensitivity reactions (including asthma and allergy) and transplantation-rejection reactions. Immunotherapeutics and vaccine development. Prerequisite: MBB 426 or HSCI 426 with a minmum grade of C. MBB 427 is identical to HSCI 427 and students cannot receive credit for both courses.

  offered Spring 2016
The molecular strategies that bacterial and viral pathogens use to colonize the human body and cause disease will be studied. Emphasis will be placed on specific microbes and their virulence factors, secretion systems, toxins and surface adhesins. Strategies for combating microbial infections - antibiotics, antiviral agents and vaccines - will be discussed in detail. Prerequisite: MBB 322 with a minimum grade of C.

  offered Summer 2016
RNA plays an important role in gene regulation. This course will explore recent primary literature studying the biochemistry of these processes. Prerequisite: MBB 331: Molecular Biology. Students who have taken MBB 420 under the same title cannot take this course for further credit.

offered Spring 2015
Analysis of mechanisms of protein, lipid, and nucleic acid delivery and transport within cells; processes of protein targeting, exocytosis, and endocytosis; molecular mechanisms of vesicle transport and membrane fusion; role in signal transduction and disease. Prerequisite: MBB 322 and MBB 331 .

offered Spring 2016
The cellular basis of selected chronic diseases such as cancer and polycystic kidney disease will be explored in-depth. Through the use of lectures and group discussions and an emphasis on the primary literature, the focus will be on recent developments in the study of these diseases. Prerequisite: MBB 322 and 331 with a minimum grade of C. Students who have taken MBB 440 under the same title cannot take this course for further credit.

MBB 432-3 Advanced Molecular Biology Techniques  
Laboratory with accompanying lectures designed to give practical experience in advanced contemporary molecular biology techniques. Lab exercises will include site-directed mutagenesis, preparation and characterization of GST-fusion proteins, construction of transgenes and their expression in transgenic organisms, and use of the yeast two-hybrid assay to study protein-protein interactions. Prerequisite: MBB 308 and 331 with a minimum grade of C.

offered Spring 2016
Lectures and student presentations will cover the wide range of ways in which organisms (primarily eukaryotes) regulate gene expression along the pathway from DNA to protein. Prerequisite: MBB 331 with a minimum grade of C.

MBB 437-3 Selected Topics in Signal Transduction offered Spring 2013
An investigation of how biochemistry, cell biology and genetics is used to study the diverse mechanisms used in cell signaling along with an exploration of how the various approaches to studying signal transduction complement each other.Prerequisite: MBB 321, MBB 322 and MBB 331 with a minimum grade of C.

offered Spring 2015
The advances in human molecular genetics including genome analysis, gene therapy, genetic testing, and studies of genetic disorders.Prerequisite: MBB 331 with a minimum grade of C.

offered Fall 2015
The topics in this course will vary from term to term, depending on faculty availability and student interest. Prerequisite: will depend upon the nature of the topic offered. Corequisite: will depend upon the nature of the topic offered.

MBB 441-3 Bioinformatics
Lectures and hands-on instruction at the computer in the use of, and theory behind, bioinformatic software and algorithms for the analysis of macromolecular data. Prerequisite: MBB 331 and MBB 342.

MBB 442-3 Proteomics offered Spring 2014
Proteomics concerns the analysis of the entire complement of proteins expressed by an organism. This course will consider protein sequence alignment, sequence database scanning, classification of protein structures, prediction of protein structure and function, and evolution of protein function. Prerequisite: MBB 321, MBB 322 and MBB 342.

MBB 443-3 Protein Biogenesis and DegradationCANCELLED - offered Summer 2016
A consideration of protein biogenesis (folding, assembly, and targeting to cellular compartments), modification, and degradation, and their roles in protein and cellular function. Prerequisite: MBB 321 and MBB 322 with a minimum grade of C.

MBB 444-3 Developmental Neurobiology
Examination of recent literature on neuronal growth cones and axonal guidance. Cell cultural, biochemical, and molecular genetic approaches will be emphasized in assessing guidance cues. Prerequisite: MBB 331 with a minimum grade of C.

offered Spring 2016
An examination of various types of cell death and cell survival mechanisms and their relationship to disease with a focus on cancer and therapeutic strategies. Students who took MBB 440 with the same title may not take MBB 446 for further credit. Prerequisite: MBB 322 and MBB 331 or permission of the instructor.

MBB 451-3 Practicum IV
Fourth term of work experience in the Molecular Biology and Biochemistry Co-operative Education Program. Units from this course do not count towards the units required for an 丁香园AV degree. Prerequisite: acceptance in the Science Co-operative Education Program.

MBB 452-3 Practicum V
Fifth term of work experience in the Molecular Biology and Biochemistry Co-operative Education Program. Units from this course do not count towards the units required for an 丁香园AV degree. Prerequisite: acceptance in the Science Co-operative Education Program.

offered Fall 2014
Examination of the fundamentals of comparative genomics, identification and activity of functional elements in genomes, inter- and intra-species comparisons, relationship of genomic to phenotypic variation, and personalized genomics are among the topics to be explored. Comparison of genome data has impacts on medicine and many other fields of the life sciences. Students who have completed MBB 440 Comparative Genomics may not complete this course for further credit.Prerequisite: MBB 331 and MBB 342.

offered Spring 2015
The organization of the human genome and the role of genomic variation in health and disease. Genomics and personalized medicine; intellectual property and privacy issues. Prerequisite: MBB 331 and MBB342 with a minimum grade of C. Students with credit for MBB 440 with this same course title may not complete this course for further credit.

offered Summer 2016
A focus on the molecular and genomic biology associated with forensic science, including genome structure, genotyping, genetic analysis of DNA fingerprints, DNA databases and CODIS, Y STRs, mtDNA and ethical considerations of DNA typing. Prerequisite: MBB 331. Students with credit for MBB 440 with this same course title may not complete this course for further credit.

MBB 471-1 Undergraduate Colloquium
Recent research articles on the molecular mechanisms underlying cellular activities or on the structure, function and interactions of macromolecules will be presented and discussed by students and faculty. This course will be available for MBB undergraduates to take once for undergraduate credit and will be offered in conjunction with MBB 821,822, 823, 861, or 863. Prerequisite: Permission of the instructor.

MBB 481-5 Individual Study Semester - Honours Thesis
Part 1 of 3-part Honours degree program, the individual study semester (ISS). The ISS provides students with the opportunity to carry out full time laboratory research in molecular biology and biochemistry. Students are required to submit a written research proposal and an Honours thesis. The grade for MBB 481 encompasses the research design aspect of the ISS, consisting of the Honours thesis. proposal and final report. Prerequisite: enrolment in the MBB, Biological Physics Honours Program, MBB308, MBB 309W and MBB 331, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the MBB department. Students may not receive credit for both MBB 481-5 and MBB 493. Required corequisites: MBB 482-5 and MBB 483-5.

MBB 482-5 Individual Study Semester - Research Performance
Part 2 of a 3-part Honours degree program, the individual study semester (ISS). The ISS provides students with the opportunity to carry out full time laboratory research in molecular biology and biochemistry. The grade for MBB 482 encompasses the research performance component of the ISS. Prerequisite: enrolment in the MBB or Biological Physics Honours Program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the MBB department. Required corequisites: MBB 481-5 and MBB 483-5.

MBB 483-5 Individual Study Semester - Honours Research Defense
Part 3 of a 3-part Honours degree program, the individual study semester (ISS). The ISS provides students with the opportunity to carry out full time laboratory research in molecular biology and biochemistry. The grade for MBB 483 encompasses the thesis defense component of the ISS. Prerequisite: enrolment in the MBB or Biological Physics Honours Program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the MBB department. Students may not receive credit for both MBB 483-5 and MBB 493-15. Corequisites: MBB 481-5 and MBB 482-5.

MBB 490-2 Directed Readings in Molecular Biology and Biochemistry
Directed reading in a topic of molecular biology or biochemistry chosen in consultation with a supervisor. Before seeking approval for enrolment in this course, the student should have already obtained the agreement of a faculty member that he/she is willing to supervise the project, and have prepared a written proposal (of approximately one page) stating the nature of the directed reading topic. The course will include the preparation of a written term paper on the topic chosen. Prerequisite: MBB 231 and permission of the molecular biology and biochemistry department. Usually, upper level standing with at least 60 units in a Biochemistry major, minor or Honours program will be required.

 MBB 491-5 Independent Study Semester
Part time laboratory research in an area of molecular biology or biochemistry for preparation of a thesis in molecular biology and biochemistry. Before seeking approval for enrolment in this course, the student should already have obtained the agreement of a 丁香园AV faculty member that he/she is willing to supervise the project, and have prepared a written proposal (of approximately 1-2 pages) stating the nature of the research project. The course will include the preparation of a written research report on the results of the project, and may also, at the discretion of the supervisor, include an oral presentation of the results. Prerequisite: MBB 231 and permission of the molecular biology and biochemistry department. Usually, upper level standing with at least 60 units in a molecular biology and biochemistry major, minor or Honours program will be required.

MBB 492-10 Individual Study Semester
Full time laboratory research in an area of molecular biology or biochemistry for preparation of a thesis for the Honours degree in molecular biology and biochemistry. This course is available to Honours students who have already taken MBB 491, or who plan to break an individual studies project into two terms (see below). The course will include the preparation of a comprehensive written research report on the results of the project, and may also, at the discretion of the supervisor, include an oral presentation of the results. Prerequisite: permission of the department.

MBB 496-6 Independent Study Semester: Joint Honours MBB-BUS or CMPT-MBB
Directed reading and part-time scientific research in an area of molecular biology or biochemistry. This course is intended only for those students taking a joint MBB/BUS or MBB/CS Honours degree. Before seeking approval for enrolment in this course, the student should already have obtained the agreement of a faculty member that he/she is willing to supervise the project, and have prepared a written proposal (of approximately 1-2 pages) stating the nature of the research readings and project. The course will include preparation of a written report on the results of the project, and may, at the discretion of the supervisor, include an oral presentation of the results. Prerequisite: 75 units and upper division standing in an MBB joint Honours program, and MBB 308. Students who take MBB 496 are not allowed to take MBB 491, 492 or 493 with the same faculty supervisor.