(1) Alteen, M. G.; Gros, C.; Meek, R. W.; Cardoso, D. A.; Busmann, J. A.; Sangouard, G.; Deen, M. C.; Tan, H.-Y.; Shen, D. L.; Russell, C. C.; Davies, G. J.; Robinson, P. J.; McCluskey, A.; Vocadlo, D. J. A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase. Angew Chem Int Ed Engl 2020, 59 (24), 9601–9609. https://doi.org/10.1002/anie.202000621.
(2) Alteen, M. G.; Meek, R. W.; Kolappan, S.; Busmann, J. A.; Cao, J.; O’Gara, Z.; Chou, Y.; Derda, R.; Davies, G. J.; Vocadlo, D. J. Phage Display Uncovers a Sequence Motif That Drives Polypeptide Binding to a Conserved Regulatory Exosite of O-GlcNAc Transferase. Proceedings of the National Academy of Sciences 2023, 120 (42), e2303690120. https://doi.org/10.1073/pnas.2303690120.
(3) Ashmus, R. A.; Wang, Y.; González-Cuesta, M.; King, D. T.; Tiet, B.; Gilormini, P.-A.; Fernández, J. M. G.; Mellet, C. O.; Britton, R.; Vocadlo, D. J. Rational Design of Cell Active C2-Modified DGJ Analogues for the Inhibition of Human α-Galactosidase A (GALA). Org. Biomol. Chem. 2021, 19 (37), 8057–8062. https://doi.org/10.1039/D1OB01526E.
(4) Ashmus, R. A.; Wang, Y.; González-Cuesta, M.; King, D. T.; Tiet, B.; Chen, X.; Zhu, Y.; Kirk, B.; GarcÃa Fernandez, J. M.; Ortiz Mellet, C.; Britton, R.; Vocadlo, D. J. Potent and Selective Cell-Active Iminosugar Inhibitors of Human α-N-Acetylgalactosaminidase (α-NAGAL). Chemistry – A European Journal 2023, 29 (44), e202300982. https://doi.org/10.1002/chem.202300982.
(5) Bhosale, S.; Deen, M. C.; Proceviat, C.; Hettle, A.; Winter, D. K.; Brockerman, J.; Levene, M.; Bennet, A. J.; Spino, C.; Boraston, A. B.; Vocadlo, D. J. A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus Pneumoniae. ACS Chem. Biol. 2023, 18 (8), 1730–1737. https://doi.org/10.1021/acschembio.3c00053.
(6) Cecioni, S.; Ashmus, R.; Gilormini, P.-A.; Zhu, S.; Shan, X.; Gros, C.; Deen, M.; Wang, Y.; Britton, R.; Vocadlo, D. Quantitative Monitoring of Glycosidase Activity in Live Cells Using Sensitive Fluorescence-Quenched Bis-Acetal Substrates. Nat Chem Biol 2020.
(7) Challa, V. R.; Kwon, D.; Taron, M.; Fan, H.; Kang, B.; Wilson, D.; Haeckl, F. P. J.; Keerthisinghe, S.; Linington, R. G.; Britton, R. Total Synthesis of Biselide A. Chem. Sci. 2021, 12 (15), 5534–5543. https://doi.org/10.1039/D0SC06223E.
(8) Corcilius, L.; Liu, D. Y.; Ochoa, J. L.; Linington, R. G.; Payne, R. J. Synthesis and Evaluation of Analogues of the Glycinocin Family of Calcium-Dependent Antibiotics. Org. Biomol. Chem. 2018, 16 (29), 5310–5320. https://doi.org/10.1039/C8OB01268G.
(9) Deen, M. C.; Proceviat, C.; Shan, X.; Wu, L.; Shen, D. L.; Davies, G. J.; Vocadlo, D. J. Selective Fluorogenic β-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates. ACS Chem. Biol. 2020, 15 (4), 824–829. https://doi.org/10.1021/acschembio.9b01044.
(10) Hawkins, P. M. E.; Liu, D. Y.; Linington, R. G.; Payne, R. J. Solid-Phase Synthesis of Coralmycin A/Epi-Coralmycin A and Desmethoxycoralmycin A. Org. Biomol. Chem. 2021, 19 (28), 6291–6300. https://doi.org/10.1039/D1OB01062J.
(11) Keefe, A. J.; Gabrych, D. R.; Zhu, Y.; Vocadlo, D. J.; Silverman, M. A. Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons. eNeuro 2023, 10 (10). https://doi.org/10.1523/ENEURO.0079-23.2023.
(12) Liu, D. Y.; Phillips, L.; Wilson, D. M.; Fulton, K. M.; Twine, S. M.; Wong, A.; Linington, R. G. Collateral Sensitivity Profiling in Drug-Resistant Escherichia Coli Identifies Natural Products Suppressing Cephalosporin Resistance. Nat Commun 2023, 14 (1), 1976. https://doi.org/10.1038/s41467-023-37624-4.
(13) Meek, R.; Blaza, J.; Busmann, J.; Alteen, M.; Vocadlo, D.; Davies, G. Cryo-EM Provides Insights into the Dimer Arrangement of OGT. Nat. Commun. 2021.
(14) Schneider, H.; Merbouh, N.; Keerthisinghe, S.; Antonietti, M.; Filonenko, S. Microwave-Irradiated Rapid Synthesis of Antimicrobial Pyrazine Derivatives in Reactive Eutectic Media. Green Chem. 2022, 24 (24), 9745–9754. https://doi.org/10.1039/D2GC03122A.
(15) Tavassoly, O.; Sade, D.; Bera, S.; Shaham-Niv, S.; Vocadlo, D. J.; Gazit, E. Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation. Journal of Molecular Biology 2018, 430 (20), 3847–3862. https://doi.org/10.1016/j.jmb.2018.08.002.
(16) Tavassoly, O.; Yue, J.; Vocadlo, D. J. Pharmacological Inhibition and Knockdown of O-GlcNAcase Reduces Cellular Internalization of α-Synuclein Preformed Fibrils. The FEBS Journal 2021, 288 (2), 452–470. https://doi.org/10.1111/febs.15349.
(17) Ueoka, R.; Bhushan, A.; Probst, S. I.; Bray, W. M.; Lokey, R. S.; Linington, R. G.; Piel, J. Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source. Angewandte Chemie International Edition 2018, 57 (44), 14519–14523. https://doi.org/10.1002/anie.201805673.
(18) Zhu, S.; Deen, M. C.; Zhu, Y.; Gilormini, P.-A.; Chen, X.; Davis, O. B.; Chin, M. Y.; Henry, A. G.; Vocadlo, D. J. A Fixable Fluorescence-Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells. Angewandte Chemie International Edition 2023, 62 (40), e202309306. https://doi.org/10.1002/anie.202309306.
(19) Zhu, Y.; Shan, X.; Safarpour, F.; Erro Go, N.; Li, N.; Shan, A.; Huang, M. C.; Deen, M.; Holicek, V.; Ashmus, R.; Madden, Z.; Gorski, S.; Silverman, M. A.; Vocadlo, D. J. Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway. ACS Chem. Neurosci. 2018, 9 (6), 1366–1379. https://doi.org/10.1021/acschemneuro.8b00015.