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MBB Graduate courses

A listing of all MBB Graduate courses, with an indication as to when they are offered, is presented below. Click on a course title to obtain the complete course description (PDF file). To assist with course planning, consult the Projected Courses guide .

offered in Spring 2016
The problem-based learning course will develop students' ability to exchange ideas in small groups focused on real but simplified problems in bioinformatics. Problems will be carefully selected to cover multiple areas of bioinformatics research. This is an advanced bioinformatics course that assumes the student has previous bioinformatics training. Prerequisite: MBB 741 or equivalent bioinformatics course (undergraduate or graduate). This course is identical to CMPT 505 and students can not take both courses for credit.

Consideration of recent research literature on contemporary topics in bioinformatics. See Supplementary Outline for more information. Prerequisites: MBB 441 or 741; or CMPT 341 or 881.

A survey of the legal, economic and social aspects of technology transfer in the areas of molecular biology, biochemistry, and biotechnology presented by a series of local experts. Topics will include patents, contracts, intellectual property, capitalization and others. The format will be a formal lecture followed by a workshop. Students with credit for MBB 400 may not take this course for further credit.

Aspects of developmental and cellular biology in the context of signal transduction pathways. The diverse mechanisms used in cell signalling and how the various approaches to the study of signal transduction in organismal development complement each other will be examined with an emphasis on current literature.

An examination of recent literature about the structure and function of DNA and RNA.

A review of recent literature on the structure, dynamics, function and biosynthesis of membrane lipids and proteins.

Mechanistic principles for how protein molecules achieve diverse functions such as chemical catalysis and conformational switching. Students will learn to critique hypotheses about structural mechanisms, and to interpret the primary literature reporting on structural evidence from X-ray diffraction and spectroscopy.

MBB 724-3 Membrane Transport Mechanisms
Structure and function of molecules that mediate transport across membranes including channels, carriers, and pumps. Primary literature from the fields of biochemistry and physiology will be explored through lectures and independent study. Prerequisite: MBB 321, 322 and either MBB 323 or CHEM 360 or permission of the instructor.

The basic organization of the immune system, including structure, function and genetics of antibodies, T-cell receptors, innate immune receptors, and the complement system. Innate, antibody and cellular immune responses and their control, and development of the cells involved in these responses. Prerequisite: MBB 331, or its equivalent, or consent of the instructor. Students who have taken MBB or HSCI 426, MBB 826 or HSCI 726 may not complete MBB 726 for credit.

offered in Spring 2016
The immunologic response to bacterial, viral and parasitic infections, immunological diseases, such as autoimmune diseases, immunodeficiency, hypersensitivity reactions (including asthma and allergy), and transplantation-rejection reactions. Immunotherapeutics and vaccine development.Prerequisite: MBB/HSCI 426 or MBB/HSCI 726 or permission of the instructor. Students with credit for MBB 427, HSCI 427 or HSCI 727 may not complete MBB 727 for credit.

offered in Summer 2016
RNA plays an important role in gene regulation. This course will explore recent primary literature studying the biochemistry of these processes. Students who have taken MBB 420 or MBB 829 under the same title cannot take this course for further credit.

Analysis of mechanisms of protein, lipid, and nucleic acid delivery and transport within cells. The course will examine processes of protein targeting,exocytosis, and endocytosis; molecular mechanisms of COP-and clathrin-mediated vesicle transport; and viral and SNARE-mediated membrane fusion.Lectures will present landmark experiments from classic papers, and student presentations will focus on recent research articles. The significance of these findings with respect to human disease and signal transduction will be considered. Prerequisite: MBB 322 and BISC 331/MBB 331 or permission of the instructor.

offered in Spring 2016
A consideration of the mechanisms and regulation of gene expression in eukaryotes and prokaryotes.

MBB 737-3 Molecular Genetics of Signal Transduction
Consideration of recent literature dealing with mechanisms of signal transduction. The emphasis of the course varies from term to term. Past offerings have ranged from a specific focus on studying signaling using molecular genetics in model organisms, to an examination of diverse cell biological, biochemical, and genetic approaches being used in current signal transduction research.

The course will consider recent advances in human molecular genetics. Topics will include genome analysis, genetic testing, and studies of genetic disorders. Prerequisite: MBB 331 (or BISC 331) or equivalent.

MBB 741-3 Bioinformatics
An overview of the newly emerging field of bioinformatics, which is loosely defined as the intersection between the fields of molecular biology and computer science. A combination of lecture format and hands-on instruction is provided in the use of, and theory behind, bioinformatic software tools used in genomic and computational biology research. An introduction to the development of bioinformatic software is included, though only basic computer science knowledge is required for this particular course. Prerequisite: one introductory computer programming course (e.g. CMPT 102, 103, 110, 120 or equivalent).

MBB 742-3 Proteomics
Since the completion of the human genome, the next step is to understand the function of these genes. Proteomics cover the integration of a number of topics with the aim of analyzing the complete complement of proteins expressed by a biological system. This course will give a general understanding of the proteome, describe many of the different aspects of proteomics that have been developed recently, identify the technologic limitations related to proteomics, and will also include likely future directions for the field. Prerequisite: one introductory computer programming course (e.g. CMPT 102, 103, 110, 120 or equivalent).

The central dogma of molecular biology (DNA to RNA to protein) underscores two fundamental biological processes, transcription and translation, that are essential to life. Protein biogenesis (folding, assembly, targeting to the proper cellular compartment), protein modification and protein degradation represent three other equally important cellular activities. The emphasis in this course will be to review the literature on protein biogenesis,function, and degradation, and explore the new and exciting developments that are just starting to uncover how mechanistically complex these processes are.