¶¡ÏãÔ°AV

Principles and concepts of the transmission of genetic information treated comparatively in man, animal, plant and microbe. Prerequisite: BISC 101 and 102 with a grade of C- or better.

The structure, function and synthesis of proteins, RNA and DNA and their interrelated biological functions within the cell. An introduction to molecular biology techniques and methods of protein purification and analysis. Prerequisite: or Corequisite CHEM 281.

A study of the molecular processes which underlie cell structure and function, integrating ultrastructural, physiological and biochemical approaches. Modern techniques used in the analysis of organelle and cell function are integral parts of the course. Prerequisite: MBB 222, BISC 101, CHEM 281 with grades of C- or better. Corequisite or Prerequisite: CHEM 282 or CHEM 283.

The study of DNA and RNA in relation to gene structure and expression: DNA replication and the regulation of gene expression in bacteria and higher organisms. Introduction to recombinant DNA and cloning theory; natural vector structures and recombinant vector construction. Prerequisite: MBB 231, and BISC 202, with a minimum grade of C.

Major topics in genomics and bioinformatics, with integrated discussion of associated ethical/legal/social issues. An overview of laboratory and computer-based methods to study genomes, and their applications. Hands-on computer lab session providing an opportunity to use and experiment with bioinformatics software and databases utilized in genomics and bioinformatics research. Prerequisite: MBB 231, BISC 202 and either MBB 243 or 3 units of CMPT or equivalent, all with a minimum grade of C. Recommended: STAT 201 (or an equivalent statistics course) or STAT 270.

Techniques in gene cloning and the evaluation of gene function are introduced in lectures and practiced in labs. Lab exercises include genomic DNA, RNA, and plasmid purification; PCR; various cloning techniques; and construction of novel genes. Students are introduced to additional techniques in lectures including gene editing, and genome sequencing. Prerequisite: BISC 202, MBB 222, and MBB 231, all with a grade of C- or better. Recommended: MBB 331. Students with credit for MBB 308 may not take this course for further credit.

Modern molecular biological and recombinant nucleic acid methods will be covered. Examples are DNA and RNA isolation, plasmid preparation, restriction enzyme digestion, DNA cloning and polymerase chain reaction. Prerequisite: or corequisite: MBB 331 with a minimum grade of C-. Students with credit for BISC 357 may not take this course for further credit.

Research methodology and associated statistical analysis techniques for students with training in the life sciences. Intended to be particularly accessible to students who are not specializing in Statistics. Prerequisite: Recommended: 30 units. Students cannot obtain credit for STAT 201 if they already have credit for - or are taking concurrently - STAT 101, 203, 205, 285, or any upper division STAT course. Quantitative.

Basic laws of probability, sample distributions. Introduction to statistical inference and applications. Prerequisite: or Corequisite: MATH 152 or 155 or 158. Students wishing an intuitive appreciation of a broad range of statistical strategies may wish to take STAT 100 first. Quantitative.

The course provides an overview of "omics" methods in large-scale identification of gene functions in various organisms, and demonstrates how this knowledge can be applied in genomics fields, including plant and animal breeding. Prerequisite: BISC 101, BISC 102, BISC 202, MBB 222, MBB 231, and either BISC 357 or MBB 331; all with a grade of C- or better. Students who have taken Special Topics BISC 471 Applied Genomics may not take this course for further credit.

Special Topics in Cells, Molecules and Physiology not currently offered in the Department of Biological Science. Prerequisite: To be announced.

Selected topics in areas not currently offered within the undergraduate course offerings in the Department of Biological Sciences. Prerequisite: To be announced.

Selected topics in Ecology, Evolution and Conservation not currently offered in the Department of Biological Science. Prerequisite: To be announced.

The topics in this course will vary from term to term, depending on faculty availability and student interest. Prerequisite: Will be announced before the start of the term and will depend upon the nature of the topic offered.

The topics in this course will vary from term to term, depending on faculty availability and student interest. Prerequisite: will depend upon the nature of the topic offered.

Examining the use of, and theory behind, bioinformatic software and algorithms for the analysis of macromolecular data. Includes consideration of recent literature and discussion of ethics in method development and analysis. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C.

The topics in this course will vary from term to term, depending on faculty availability and student interest. Students may repeat this course for further credit under a different topic. Prerequisite: Will vary depending on the topic.

Examination of the fundamentals of comparative genomics, identification and activity of functional elements in genomes, inter- and intra-species comparisons, relationship of genomic to phenotypic variation, and personalized genomics are among the topics to be explored. Comparison of genome data has impacts on medicine and many other fields of the life sciences. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C. Students who have completed MBB 440 Comparative Genomics may not complete this course for further credit.

The organization of the human genome and the role of genomic variation in health and disease. Genomics and personalized medicine; intellectual property and privacy issues. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C. Students with credit for MBB 440 with this same course title may not complete this course for further credit.

A focus on the molecular and genomic biology associated with forensic science, including genome structure, genotyping, genetic analysis of DNA fingerprints, DNA data bases and CODIS, Y STRs. mtDNA and ethical considerations of DNA typing. Prerequisite: MBB 331, with a minimum grade of C.

Methods that enable the integration of Biochemical, Genetic and Genomic knowledge (BiGG) to reconstruct a genomic scale network that defines the metabolic physiology of an organism will be explored. Applications of these approaches in the fields of microbial evolution, interaction networks, genetic engineering and drug discovery will be discussed. Prerequisite: MBB 331 and MBB 342.