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The structure, function and synthesis of proteins, RNA and DNA and their interrelated biological functions within the cell. An introduction to molecular biology techniques and methods of protein purification and analysis. Prerequisite: or Corequisite CHEM 281.

A study of the molecular processes which underlie cell structure and function, integrating ultrastructural, physiological and biochemical approaches. Modern techniques used in the analysis of organelle and cell function are integral parts of the course. Prerequisite: MBB 222, BISC 101, CHEM 281 with grades of C- or better. Corequisite or Prerequisite: CHEM 282 or CHEM 283.

Principles and concepts of the transmission of genetic information treated comparatively in man, animal, plant and microbe. Prerequisite: BISC 101 and 102 with a grade of C- or better.

The study of DNA and RNA in relation to gene structure and expression: DNA replication and the regulation of gene expression in bacteria and higher organisms. Introduction to recombinant DNA and cloning theory; natural vector structures and recombinant vector construction. Prerequisite: MBB 231, and BISC 202, with a minimum grade of C.

Major topics in genomics and bioinformatics, with integrated discussion of associated ethical/legal/social issues. An overview of laboratory and computer-based methods to study genomes, and their applications. Hands-on computer lab session providing an opportunity to use and experiment with bioinformatics software and databases utilized in genomics and bioinformatics research. Prerequisite: MBB 231, BISC 202 and 3 units of CMPT or equivalent, with a minimum grade of C.

Modern molecular biological and recombinant nucleic acid methods will be covered. Examples are DNA and RNA isolation, plasmid preparation, restriction enzyme digestion, DNA cloning and polymerase chain reaction. Prerequisite: MBB 231, and MBB 331 as a co- or pre-requisite (the latter is recommended), with a minimum grade of C. Students with credit for BISC 357 may not take this course for further credit.

Introduction to various techniques in gene cloning and the applications of gene cloning. Laboratory exercises follow a sequence of events commonly practiced in many molecular genetics laboratories and include novel technologies such as cloning by site-directed recombination. Lecture content spans basic cloning in plasmids to novel large-scale genomics technologies. Prerequisite: BISC 202, MBB 222, 231 with a grade of C- or better. Recommended: MBB 331. Students with credit for MBB 308, or a Special Topics course under this topic, may not take this course for further credit.

Research methodology and associated statistical analysis techniques for students with training in the life sciences. Intended to be particularly accessible to students who are not specializing in Statistics. Prerequisite: 30 units. Students with credit for any of STAT 101, 203 or 270 may not take STAT 201 for further credit,. Quantitative.

Basic laws of probability, sample distributions. Introduction to statistical inference and applications. Corequisite: MATH 152 or 155 or 158. Students wishing an intuitive appreciation of a broad range of statistical strategies may wish to take STAT 100 first. Quantitative.

The analysis of entire genomes of organisms has only been possible since 1995. This new area of study will be examined in detail with emphasis on current research. Prerequisite: MBB 331 with a minimum grade of C.

Lectures and hands-on instruction at the computer in the use of, and theory behind, bioinformatic software and algorithms for the analysis of macromolecular data. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C.

Proteomics concerns the analysis of the entire complement of proteins expressed by an organism. This course will consider protein sequence alignment, sequence database scanning, classification of protein structures, prediction of protein structure and function, and evolution of protein function. Prerequisite: MBB 321, MBB 322 and MBB 342, with a minimum grade of C.

Examination of the fundamentals of comparative genomics, identification and activity of functional elements in genomes, inter- and intra-species comparisons, relationship of genomic to phenotypic variation, and personalized genomics are among the topics to be explored. Comparison of genome data has impacts on medicine and many other fields of the life sciences. Prerequisite: MBB 331 and MBB 342. Students who have completed MBB 440 Comparative Genomics may not complete this course for further credit.

The organization of the human genome and the role of genomic variation in health and disease. Genomics and personalized medicine; intellectual property and privacy issues. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C. Students with credit for MBB 440 with this same course title may not complete this course for further credit.

The topics in this course will vary from term to term, depending on faculty availability and student interest. Prerequisite: Will be announced before the start of the term and will depend upon the nature of the topic offered.

The topics in this course will vary from term to term, depending on faculty availability and student interest. Prerequisite: will depend upon the nature of the topic offered.

Special Topics in Cells, Molecules and Physiology not currently offered in the Department of Biological Science. Prerequisite: To be announced.

Selected topics in areas not currently offered within the undergraduate course offerings in the Department of Biological Sciences. Prerequisite: To be announced.

Selected topics in Ecology, Evolution and Conservation not currently offered in the Department of Biological Science. Prerequisite: To be announced.