丁香园AV

Areas of interest

We are studying inflammasomes that we discovered in genomics databases which are innate immune system receptors and cytosolic sensors that recognize and sense microbial debris. They produce inflammation in response to infection by microbes and are disregulated in Alzheimer, Parkinson, Cancer, Diabetes chronic diseases. We are using bioinformatics to integrate BIG-OMICS data sets and identify pathways components involved in these processes. Ultimately these developments will point toward promising therapeutics that target inflammasome activity. Our current projects include but are not restricted to:

-Innate immunity pathway discovery in C. elegans
-Evolution of Innate immunity pathways
-Drug discovery in silico that target inflammation
-Target identification and validation using C. elegans and other model organisms